Single-molecule imaging of EGFR signalli
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Yanagida, Toshio; Sako, Yasushi; Minoghchi, Shigeru
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Article
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2000
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Nature Publishing Group
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English
β 313 KB
The early events in signal transduction from the epidermal growth factor (EGF) receptor (EGFR) are dimerization and autophosphorylation of the receptor, induced by binding of EGF. Here we observe these events in living cells by visualizing single molecules of fluorescent-dye-labelled EGF in the plas