✦ LIBER ✦

Single-molecule fluorescence of nucleic acids

✍ Scribed by Emilia T Mollova

Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 113 KB
Volume: 6
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(02)00394-0

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✦ Synopsis

Less than a decade old, single-molecule fluorescence of nucleic acids has rapidly become an important tool in the arsenal of biological probes. A variety of novel approaches to investigate conformational dynamics, catalytic mechanisms, folding pathways and protein-nucleic-acid interactions have recently been devised for nucleic acids using this technique. Combined with biomechanical tools and ensemble measurements, single-molecule fluorescence methods extend our ability to observe and understand biomolecules and complex biological processes.

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