Single dose pharmacokinetics of proguani
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Wangboonskul, J. (author);White, N. J. (author);Nosten, F. (author);ter Kuile, F
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Article
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1993
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Springer-Verlag
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English
β 491 KB
Plasma and whole blood concentrations of proguanil, its active metabolite cycloguanil, and the inactive metabolite 4-chlorophenyl-biguanide, were measured by HPLC in 10 healthy Karen women in the last trimester of pregnancy, following a 200 mg single oral dose of proguanil. Four of these women were