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Single-Dose, First-in-Human Study of AMG 317: Pharmacokinetics and Safety in Healthy and Asthmatic Adults

โœ Scribed by VINCENT, M; BANFIELD, C; KAKKAR, T; SHAKIB, S; SCHICCHITANO, R; CHEAH, T; GERSON, J

Book ID
119279635
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
47 KB
Volume
121
Category
Article
ISSN
1097-6825

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The pharmacokinetics and tolerability of a new putative non-benzodiazepine type anxiolytic compound deramciclane was studied in two consecutive studies. An open dose-escalation design was used to study doses from 0.2 to 50 mg in 18 healthy male volunteers. In the second study doses from 50 to 150 mg