Single channel recordings of reconstituted ion channel proteins: an improved technique
β Scribed by Bernhard U. Keller; Rainer Hedrich; Winchil L. C. Vaz; Manuel Criado
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 957 KB
- Volume
- 411
- Category
- Article
- ISSN
- 0031-6768
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The single-channel recording technique has revolutionized the electrophysiological study of the ion channels. Interpretation of single-channel recordings often requires the exact number of channels present in a given patch-for example, derivation of the probability of a channel being open-and most t
The Akaike information criterion (AIC) and other criteria that trade off the goodness-of-fit against the number of parameters have been used to determine the number of ion channel states from single channel recordings. We show that, in general, such criteria are not valid. This is illustrated by an