Single cell translocations in couples with multiple spontaneous abortions

✍ Scribed by Michael D. Higgins; Catherine G. Palmer

• Publisher: Springer
• Year: 1987
• Tongue: English
• Weight: 377 KB
• Volume: 75
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00273833

✦ Synopsis

Single cell translocations have been previously reported to occur in normal lymphocyte cultures. Comparison of the frequency of these in 140 individuals referred for a history of multiple miscarriages and 415 individuals referred for a history of multiple miscarriages and 415 individuals referred for other reasons showed a significantly greater number of single cell translocations in the former group. This group also had a significantly greater number of other types of single cell structural abnormalities. Increased chromosome instability, chromosome mosaicism, residual fetal trophoblasts, and immunological differences are discussed in considering the possible etiology.