Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan
β Scribed by R. H. BARBHAIYA; A. B. BUCH; D. S. GREENE
- Book ID
- 108639943
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 776 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0306-5251
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The single-dose pharmacokinetics of nefazodone (NEF) and its metabolites hydroxynefazodone (HO-NEF) and m-chlorophenylpiperazine (mCPP) were examined in 12 healthy younger subjects < 55 years of age (YNG), 12 elderly subjects > 65 years of age (ELD), 12 patients with biopsy proven hepatic cirrhosis