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Single- and multiple-dose pharmacokinetics of nefazodone in patients with hepatic cirrhosis

✍ Scribed by Barbhaiya, Rashmi H.; Shukla, Umesh A.; Natarajan, Chandra S.; Behr, Douglas A.; Greene, Douglas S.; Sainati, Stephen M.


Book ID
107740692
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
951 KB
Volume
58
Category
Article
ISSN
0009-9236

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The single-dose pharmacokinetics of nefazodone (NEF) and its metabolites hydroxynefazodone (HO-NEF) and m-chlorophenylpiperazine (mCPP) were examined in 12 healthy younger subjects < 55 years of age (YNG), 12 elderly subjects > 65 years of age (ELD), 12 patients with biopsy proven hepatic cirrhosis