Single- and multiple-dose pharmacokinetics of nefazodone in patients with hepatic cirrhosis
β Scribed by Barbhaiya, Rashmi H.; Shukla, Umesh A.; Natarajan, Chandra S.; Behr, Douglas A.; Greene, Douglas S.; Sainati, Stephen M.
- Book ID
- 107740692
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 951 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0009-9236
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The plasma concentration-time curve of the hydrolysis product of bopindolol has been investigated in 14 patients with cirrhosis and in 15 healthy volunteers given a single oral dose of 2 mg bopindolol. Cirrhosis was confirmed by history and clinical examination or liver biopsy. The time to maximum c
The single-dose pharmacokinetics of nefazodone (NEF) and its metabolites hydroxynefazodone (HO-NEF) and m-chlorophenylpiperazine (mCPP) were examined in 12 healthy younger subjects < 55 years of age (YNG), 12 elderly subjects > 65 years of age (ELD), 12 patients with biopsy proven hepatic cirrhosis