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Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway

✍ Scribed by Dionysios Chartoumpekis; Panos G. Ziros; Agathoklis Psyrogiannis; Venetsana Kyriazopoulou; Athanasios G. Papavassiliou; Ioannis G. Habeos


Book ID
116300242
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
747 KB
Volume
396
Category
Article
ISSN
0006-291X

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Nrf2/HO-1 pathway activation by manganes
✍ Huangyuan Li; Siying Wu; Nian Shi; Shuangqing Lian; Wei Lin πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 624 KB

## ABSTRACT Manganese has been known to induce neurological disorders similar to Parkinson's disease. One of the features of manganese‐induced neurotoxicity is oxidative stress. Accumulating data implicate NF‐E2‐related factor 2 (Nrf2) as a key regulator in the adaptive survival response to oxidati