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Simultaneous targeting of IL2 and IL12 to Hodgkin's lymphoma cells enhances activation of resting NK cells and tumor cell lysis

✍ Scribed by Andreas Hombach; Claudia Heuser; Hinrich Abken

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
139 KB
Volume
115
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Hodgkin's disease (HD) is characterized by the accumulation of functionally anergic T cells in the vicinity of the malignant Hodgkin/Reed‐Sternberg (H/RS) cells. To revert cellular anergy against H/RS cells, we generated an anti‐CD30‐antibody‐interleukin‐(IL)‐2 and an anti‐CD30‐antibody‐IL12 fusion protein that target IL2 and IL12, respectively, specifically to CD30^+^ H/RS cells. Both antibody‐cytokine fusion proteins act cooperatively in the activation of resting NK cells, the induction of IFN‐gγ secretion and enhanced target cell lysis. The cooperative activity of the targeted cytokines suggests that the application of both antibody‐cytokine fusion proteins may be particularly suitable for the specific immunotherapy of Hodgkin's lymphoma. © 2005 Wiley‐Liss, Inc.

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