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Simultaneous Stimulation with TGF-β1 and TNF-α Induces Epithelial Mesenchymal Transition in Bronchial Epithelial Cells

✍ Scribed by Kamitani, Sumiko; Yamauchi, Yasuhiro; Kawasaki, Shin; Takami, Kazutaka; Takizawa, Hajime; Nagase, Takahide; Kohyama, Tadashi

Book ID: 120469982
Publisher: S. Karger AG
Year: 2011
Tongue: English
Weight: 951 KB
Volume: 155
Category: Article
ISSN: 1018-2438
DOI: 10.1159/000318854

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## Abstract Idiopathic pulmonary fibrosis is characterized by myofibroblast accumulation, extracellular matrix (ECM) remodeling, and excessive collagen deposition. ECM‐producing myofibroblasts may originate from epithelial cells through epithelial to mesenchymal transition (EMT). TGF‐β1 is an induc