Simultaneous Solid Phase Extraction, Derivatization, and Gas Chromatographic Mass Spectrometric Quantification of Thromboxane and Prostacyclin Metabolites, Prostaglandins, and Isoprostanes in Urine
✍ Scribed by Wübert, Joachim; Reder, Elke; Kaser, Andrea; Weber, Peter C.; Lorenz, Reinhard L.
- Book ID
- 126970122
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 239 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0003-2700
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A novel automatic system has been developed for the rapid solid-extraction and derivatization of different drugs and their metabolites from urine, prior to further analysis. Manual injection of underivatized/derivatized drugs in a GC/MS system, in which the quadrupole mass filter was operated conven
## Abstract A simple and rapid GC‐MS method has been developed for the screening and quantification of many illicit drugs and their metabolites in human urine by using automatic SPE and trimethylsilylation. Sixty illicit drugs, including parent drugs and their metabolites that are possibly abused i