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Simultaneous Quantitation of Tetrahydropalmatine and Protopine in Rabbit Plasma by HPLC–PAD, and Application to Pharmacokinetic Studies

✍ Scribed by Zhi-Chao Fan; Cai-Juan Xie; Zhi-Qi Zhang


Book ID
119987891
Publisher
Springer
Year
2006
Tongue
English
Weight
248 KB
Volume
64
Category
Article
ISSN
0009-5893

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## Abstract A specific, accurate, precise and reproducible high‐performance liquid chromatography (HPLC) method was developed for the estimation of ragaglitazar [(−) DRF 2725, NNC 61‐0029], a novel anti‐diabetic agent, in rat plasma. The assay procedure involved simple liquid/liquid extraction of r