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Simultaneous quantification of mefloquine (+)- and (−)-enantiomers and the carboxy metabolite in dried blood spots by liquid chromatography/tandem mass spectrometry

✍ Scribed by Geditz, Mirjam C.K.; Lindner, Wolfgang; Lämmerhofer, Michael; Heinkele, Georg; Kerb, Reinhold; Ramharter, Michael; Schwab, Matthias; Hofmann, Ute

Book ID
122428706
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
978 KB
Volume
968
Category
Article
ISSN
1873-376X

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## Abstract Orotic acid (ORA) is an intermediate metabolite in the pathway of pyrimidine nucleotides; its urinary excretion is useful to diagnose the hereditary orotic aciduria and some hyperammonemic inherited defects of urea cycle enzymes and amino acid transporters. ORA analysis is based on stab