Simultaneous Protection and Activation of Amino Acids Using Propargyl Pentafluorophenyl Carbonate.
β Scribed by Ramapanicker Ramesh; Sakthidevi Rajasekaran; Rohit Gupta; Srinivasan Chandrasekaran
- Book ID
- 101995589
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 20 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Protection of the amino group and activation of the carboxylic acid groups are the most important steps associated with any peptide synthesis protocol; hence, a oneβpot process to achieve these is highly desirable. A possible strategy is to use pentafluorophenyl carbonates to simultaneo
Reaction of L-phenylalanine (1) with dichlorodimethylsilane or other dichlorosilane derivatives 6b-d and primary amines leads to the formation of amides probably via a cyclic silyl intermediate. It is also possible to use b-amino acids and N-alkylated amino acids (peptoid building blocks) as well as