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Simultaneous occurrence of acute myeloid leukaemia with mutated nucleophosmin (NPM1) in the same family

✍ Scribed by Cazzaniga, G; Lo Nigro, L; Cifola, I; Milone, G; Schnittger, S; Haferlach, T; Mirabile, E; Costantino, F; Martelli, M P; Mastrodicasa, E


Book ID
109886526
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
445 KB
Volume
23
Category
Article
ISSN
0887-6924

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Nucleophosmin mutations of exon 12 (NPM1 mutations) represent the most frequent molecular aberration that can be found in patients with acute myeloid leukaemia (AML) and can be detected in about 35% of AML patients. NPM1 mutations are characterised by four basepair insertions within the region corre