𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications

✍ Scribed by Falini, B; Bolli, N; Liso, A; Martelli, M P; Mannucci, R; Pileri, S; Nicoletti, I


Book ID
109886870
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
747 KB
Volume
23
Category
Article
ISSN
0887-6924

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Nucleophosmin (NPM1) mutations in adult
✍ Rachel Rau; Patrick Brown πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 154 KB

## Abstract Nucleophosmin (NPM) is a ubiquitously expressed chaperone protein that shuttles rapidly between the nucleus and cytoplasm, but predominantly resides in the nucleolus. It plays key roles in ribosome biogenesis, centrosome duplication, genomic stability, cell cycle progression and apoptos

Rapid screening and sensitive detection
✍ S. Scholl; L.-O. MΓΌgge; O. Landt; I.F. Loncarevic; C. Kunert; J.H. Clement; K. H πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 782 KB

Nucleophosmin mutations of exon 12 (NPM1 mutations) represent the most frequent molecular aberration that can be found in patients with acute myeloid leukaemia (AML) and can be detected in about 35% of AML patients. NPM1 mutations are characterised by four basepair insertions within the region corre