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Simultaneous Lactate Editing and Observation of Other Metabolites Using a Stimulated-Echo-Enhanced Double-Quantum Filter

✍ Scribed by Hao Lei; James Peeling

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
82 KB
Volume
137
Category
Article
ISSN
1090-7807

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✦ Synopsis

Conventional double-quantum editing techniques recover only one metabolite at a time, and are thus inefficient for monitoring metabolic changes involving several metabolites. In this paper, a stimulated-echo-enhanced selective double-quantum coherence transfer (STE-SelDQC) sequence is described, which allows simultaneous observation of lactate and other metabolites in a single scan while leaving fat and water signals suppressed. A frequency selective double-quantum filter designed for lactate editing suppresses fat and water resonances and a stimulated-echo window of adjustable frequency and bandwidth is incorporated into the double-quantum filter for simultaneous observation of other metabolites. The performance of the sequence is demonstrated in phantoms and rat brain tissue.

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## Abstract ^1^H NMR simultaneous editing of ^13^C‐coupled and ^13^C‐uncoupled methyl protons resonance, using the selection of double quantum coherences by a gradient pulse, was analyzed __in vitro__ and demonstrated __in situ on__ the hindlimb of an exercised rat model postmortem. __In vitro__ ca