Simultaneous labelling with stable and radioactive isotopes in drug metabolism studies
β Scribed by Arno Zimmer; Axel Prox; Helmut Pelzer; Rainer Hankwitz
- Book ID
- 115771466
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- English
- Weight
- 680 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0006-2952
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We present a novel method for performing pharmacokinetic and metabolism studies on macromolecules that offers advantages over the existing techniques of radiolabeling, immunoassay or bioassays. Our strategy uses macromolecules with stable isotopes uniformly distributed throughout the structure. The
Internal reference compounds labeled with stable isotopes have been used to quantify drugs and drug metabolites in urine, plasma and breast milk. [2,4,5J%&]Diphenylhydantoin, [2,4,5J3C3]phenobarbital and [I-CZH3]valium have been used to quantify diphenylhydantoin, phenobarbital and Valium, respectiv
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