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Simultaneous imaging and R2* mapping using a radial multi-gradient-echo (rMGE) sequence

✍ Scribed by Stefanie Winkelmann; Tobias Schaeffter; Steffen Weiss; Holger Eggers; Olaf Doessel

Book ID
102374368
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
445 KB
Volume
24
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To demonstrate a rapid MR technique that combines imaging and R2* mapping based on a single radial multi‐gradient‐echo (rMGE) data set. The technique provides a fast method for online monitoring of the administration of (super‐)paramagnetic contrast agents as well as image‐guided drug delivery.

Materials and Methods

Data are acquired using an rMGE sequence, resulting in interleaved undersampled radial k‐spaces representing different echo times (TEs). These data sets are reconstructed separately, yielding a series of images with different TEs used for pixelwise R2* mapping. A fast numerical algorithm implemented on a real‐time reconstruction platform provides online estimation of the relaxation rate R2*. Simultaneously the images are summed for the computation of a high‐resolution image.

Results

Convenient high‐resolution R2* maps of phantoms and the liver of a healthy volunteer were obtained. In addition to stable intrinsic baseline maps, the proposed technique provides particularly accurate results for the high relaxation rates observed during the presence of (super‐)paramagnetic contrast agents. Assuming that the change in R2* is proportional to the concentration of the agent, the technique offers a rough estimate for dynamic dosage.

Conclusion

The simultaneous online display of morphological and parametric information permits convenient, quantitative surveillance of contrast‐agent administration. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.

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