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Simultaneous GLC determination of phenylpropanolamine and chlorpheniramine in urine using a nitrogen selective detector

โœ Scribed by H. Kinsun; M. A. Moulin; E. C. Savini

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
225 KB
Volume
67
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

A simple, rapid, and sensitive simultaneous quantitative determination of phenylpropanolamine and chlorpheniramine in human urine by GLC, using a nitrogen specific detector, is described. After alkaline extraction from urine, phenylpropanolamine and chlorpheniramine are analyzed directly by GLC, without a derivatization step. Promethazine was used as the internal standard. The total assay time is less than 30 min. The method is useful in studies of pharmacokinetic and pharmacological interactions of drug combinations.

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โœ Sy-Rong Sun; D. J. Hoffman ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 293 KB ๐Ÿ‘ 1 views

A GLC method for the analysis of pentobarbital in serum was developed. After extraction from serum, a methyl derivative was prepared and quantitated by nitrogen-specific detection. The method has a senstivity of 0.08 microgram/ml for pentobarbital with only 0.1 ml of serum. Secobarbital was the inte