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Rapid, sensitive GLC determination of pentobarbital and other barbiturates in serum using nitrogen-specific detector

✍ Scribed by Sy-Rong Sun; D. J. Hoffman


Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
293 KB
Volume
68
Category
Article
ISSN
0022-3549

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✦ Synopsis


A GLC method for the analysis of pentobarbital in serum was developed. After extraction from serum, a methyl derivative was prepared and quantitated by nitrogen-specific detection. The method has a senstivity of 0.08 microgram/ml for pentobarbital with only 0.1 ml of serum. Secobarbital was the internal standard. Derivatives of other barbiturates also were prepared.