Simultaneous expression of the ras p21 and p53 proteins in human endometrial carcinomas
โ Scribed by Roman Miturski; Andrzej Semczuk; Jerzy Jakowicki
- Book ID
- 117259280
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- German
- Weight
- 841 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0065-1281
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The p21 protein inhibits cyclin-dependent kinases and mediates cell-cycle arrest and cell differentiation. It is induced by wild-type p53, but not by mutant p53. This study of 75 patients with endometrial carcinoma investigates the relationship between p21 expression and the functional status of p53
## Abstract In order to investigate the value of ras oncogene expression as a prognostic indicator in esophageal squamous cell carcinoma, we evaluated the level of ras oncogene protein product (p21) in 52 specimens resected between 1977 and 1986. All patients were followed until death or for at lea