A liquid chromatography‐electrospray ionization tandem mass spectrometry method was developed and validated for the simultaneous quantitation of nicorandil and its denitrated metabolite, __N__‐(2‐hydroxyethyl)‐nicotinamide, in rat plasma. After a liquid–liquid extraction step, chromatographic separa
Simultaneous Estimation of Vinpocetine and Its Metabolite, Apovincaminic Acid, in Beagle Plasma by LC-MS-MS
✍ Scribed by Yuan Yang; Kun Lou; Wei Gong; Xing-Guo Mei; Kai-Chun Zhang
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 341 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0009-5893
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The pharmacokinetics of vinpocetine (ethyl apovincaminate, Cavinton) and its metabolite, apovincaminic acid, was studied in patients with cerebrovascular disorders. Vinpocetine (1 mg/kg) was infused intravenously over 25 min. The elimination half-life of the parent drug in plasma was 4.7k2.13 h. Tot