Simultaneous determination of propranolol and pindolol by synchronous spectrofluorimetry

✍ Scribed by Tomás Pérez Ruiz; Carmen Martı́nez-Lozano; Virginia Tomás; José Carpena

• Book ID: 117224277
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 146 KB
• Volume: 45
• Category: Article
• ISSN: 0039-9140
• DOI: 10.1016/s0039-9140(97)00203-8

✦ Synopsis

The simultaneous determination of propranolol and pindolol using synchronous fluorescence spectrometric techniques is described. The method involves measuring the natural fluorescence of these drugs in a 50% (v/v) ethanol-water medium using zero and first derivative synchronous spectrofluorimetry. Under the optimum conditions, the linear determination ranges of propanolol and pindolol are ca. 0.02 -1.0 and 0.04 -1.2 mg ml -1 , respectively. The results showed that propranolol and pindolol can be determined simultaneously when the concentration ratio of propranolol to pindolol varies from 1:100 to 50:1 in the mixed sample. The method has been satisfactorily applied to the determination of propranolol and pindolol in urine samples and propranolol in pharmaceutical preparations.