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Simultaneous Determination of Pethidine and Atropine in Rabbit Plasma by LC–MS–MS and Its Application to a Pharmacokinetic Study after Intramuscular Administration

✍ Scribed by Chan Chen; Jie Deng; Shougang Wang; Jiejin Zhu; Meifei Lu; Hongzhang He; Yinping Fu; Xianqin Wang; Jianshe Ma

Publisher: Springer
Year: 2011
Tongue: English
Weight: 337 KB
Volume: 73
Category: Article
ISSN: 0009-5893
DOI: 10.1007/s10337-011-2011-9

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## Abstract A rapid, simple, sensitive and specific LC‐MS/MS method has been developed and validated for the simultaneous estimation of atorvastatin (ATO), amlodipine (AML), ramipril (RAM) and benazepril (BEN) using nevirapine as an internal standard (IS). The API‐4000 LC‐MS/MS was operated under t