Simultaneous determination of NK611, a novel water-soluble derivative of etoposide, and its metabolite (DeNK611) in dog plasma by column-switching high performance liquid chromatography
β Scribed by Megumi Machida; Shigeo Tanaka; Kota Nakamori
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 332 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0269-3879
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A specific HPLC method for the simultaneous determination of YM928, a novel noncompetitive AMPA receptor antagonist, and its demethylated metabolite (YM-58875) in rat, dog and monkey plasma was developed and validated. The method utilized multiple-step liquid-liquid extraction followed by a reversed
A liquid chromatographic/mass spectrometric (LC/MS) assay was developed for the simultaneous determination of a pro-drug (Ro 48-3657), its active metabolite (platelet inhibitor, Ro 44-3888) and precursor metabolite (Ro 48-3656) in human, dog and rat plasma, utilizing on-line column-switching solid-p