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Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: Application to a pharmacokinetic study

✍ Scribed by J.L. Donato; F. Koizumi; A.S. Pereira; G.D. Mendes; G. De Nucci

Book ID: 116620775
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 730 KB
Volume: 899
Category: Article
ISSN: 1873-376X
DOI: 10.1016/j.jchromb.2012.05.001

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## Abstract A highly sensitive, rapid assay method has been developed and validated for the estimation of omeprazole (OPZ) in human plasma with liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive‐ion mode. The assay procedure involves alkalinizatio