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Simultaneous determination of desloratadine and its active metabolite 3-hydroxydesloratadine in human plasma by LC/MS/MS and its application to pharmacokinetics and bioequivalence

✍ Scribed by Hong-Rong Xu; Xue-Ning Li; Wei-Li Chen; Nan-Nan Chu

Book ID
108189433
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
555 KB
Volume
45
Category
Article
ISSN
0731-7085

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## Abstract A rapid, simple, sensitive and specific LC‐MS/MS method has been developed and validated for the simultaneous estimation of atorvastatin (ATO), amlodipine (AML), ramipril (RAM) and benazepril (BEN) using nevirapine as an internal standard (IS). The API‐4000 LC‐MS/MS was operated under t