Simultaneous determination of a new anthracycline, DA-125, and its metabolites M1, M2, M3 and M4 in plasma and urine by high-performance liquid chromatography
✍ Scribed by Hyun Joo Shim; Eung Doo Lee; Eun Jeong Yoon; Sang Deuk Lee; Won Bae Kim; Junnick Yang; Myung Gull Lee
- Publisher
- Elsevier Science
- Year
- 1994
- Weight
- 345 KB
- Volume
- 656
- Category
- Article
- ISSN
- 0378-4347
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The pharmacokinetics of M1 -M4, the metabolites of a new anthracycline antineoplastic agent, DA-125, were compared after intravenous (IV) administration of DA-125, 15 mg kg -1 , to rats pretreated with enzyme inducers, such as phenobarbital (PBT, n =14) and 3-methylcholanthrene (MCT, n= 15), or enzy
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