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Simultaneous determination of 5′-deoxy-5-fluorouridine, 5-fluorouracil and its main metabolites in body fluids by HPLC

✍ Scribed by F. Palmisano; F. Berardi; M. De Lena; A. Guerrieri; V. Lorusso; P. G. Zambonin


Book ID
112720493
Publisher
Springer
Year
1992
Tongue
English
Weight
442 KB
Volume
33
Category
Article
ISSN
0009-5893

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Simultaneous determination of 5′-deoxy-5
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A gas chromatography-mass spectrometry (GC-MS) method for the simultaneous determination of 5'-deoxy-Sfluorouridine (doxifluridine, 5'-dFUR), 5fluorouracil (5-FU) and its main catabolite 5,6-dihydro-5-fluorouracil (5-FUH\*) in human plasma has been developed. Sample preparation consisted of protein

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✍ Guerrieri; F. Palmisano; C.G. Zambonin; M. De Lena 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 688 KB

Dihydro-5-fluorouracluorouracil(5-lWH~) , the maiu catabolite of the anticancer drug 54uorouraeil( WU), can be quantitated iu human serum simultaueously with the pro-drug 5'-deoxy-5-f (5'dFWR), the parent drug 5-PU and the aaabolites 5-fluorouridine and 2'-deoxy-5-f by gradient elution-reversed phas