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Simultaneous Assessment of Uptake and Metabolism in Rat Hepatocytes: A Comprehensive Mechanistic Model

✍ Scribed by Menochet, K.; Kenworthy, K. E.; Houston, J. B.; Galetin, A.

Book ID
115505970
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2011
Tongue
English
Weight
838 KB
Volume
341
Category
Article
ISSN
0022-3565

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Hypoxic conformance of metabolism in pri
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✍ Ram M. Subramanian; Navdeep Chandel; G. R. Scott Budinger; Paul T. Schumacker πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 361 KB πŸ‘ 1 views

Following prolonged hypoxia, mammalian cells invoke adaptive mechanisms to enhance oxygen delivery and promote energy conservation. We previously reported that hepatocytes subjected to prolonged moderate hypoxia (PO2 = 20-50 mmHg for > 3 hours) demonstrated a reversible inhibition of cellular respir