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In vitro metabolism and toxicity assessment of N-methylcarbazole in primary cultured rat hepatocytes

โœ Scribed by Wei Yang; Tianrong Jiang; Patrick J. Davis; Daniel Acosta


Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
429 KB
Volume
68
Category
Article
ISSN
0300-483X

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## Abstract The study examined the feasibility of screening for hepatotoxicity by an __in vitro__ gene expression analysis using rat primary hepatocytes and Affymetrix Rat Toxicology U34 arrays. Hepatocytes were exposed for 6 or 24 h to eight drugs, with different mechanisms of hepatotoxicity, at o