✦ LIBER ✦

Preparation of primary cultures of rat hepatocytes suitable for in vitro toxicity testing

✍ Scribed by Kathryn A. Elliget; Gerald J. Kolaja

Publisher: Springer
Year: 1983
Tongue: English
Weight: 679 KB
Volume: 8
Category: Article
ISSN: 1573-0603
DOI: 10.1007/bf01834627

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

In vitro metabolism and toxicity assessm

In vitro metabolism and toxicity assessment of N-methylcarbazole in primary cultured rat hepatocytes

✍ Wei Yang; Tianrong Jiang; Patrick J. Davis; Daniel Acosta 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 429 KB

Preparation of primary monolayer culture

Preparation of primary monolayer cultures of adult rat hepatocytes

✍ Gary L. Engelmann; Joshua A. Fierer 📂 Article 📅 1982 🏛 Springer 🌐 English ⚖ 490 KB

Mechanism of toxicity of precocene II in

Mechanism of toxicity of precocene II in rat hepatocyte cultures

✍ Hammond, Alison H. ;Garle, Michael J. ;Fry, Jeffrey R. 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 907 KB

Precocene I1 was more toxic in 24 hour cultures than in 72 hour cultures of rat hepatocytes. In 24 hour cultures, there was no observable toxicity at 75 pM precocene I1 after exposure for 6 hours, but after 24 hours, 65% of the cells were dead. In contrast, although 794 pM killed 50% of the cells in

Bile acid synthesis in primary cultures

Bile acid synthesis in primary cultures of rat and human hepatocytes

✍ Ewa Ellis; Bryan Goodwin; Anna Abrahamsson; Chris Liddle; Agneta Mode; Mats Rudl 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB

Wheat extracts as an efficient cryoprote

Wheat extracts as an efficient cryoprotective agent for primary cultures of rat hepatocytes

✍ Francine Hamel; Mélanie Grondin; Francine Denizeau; Diana A. Averill-Bates; Fath 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 342 KB

Hepatocytes are an important physiological model for evaluation of metabolic and biological effects of xenobiotics. They do not proliferate in culture and are extremely sensitive to damage during freezing and thawing, even after the addition of classical cryoprotectants. Thus improved cryopreservati

In vitro gene expression analysis of hep

In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes

✍ Hiromi Suzuki; Tomoaki Inoue; Tomochika Matsushita; Kazuko Kobayashi; Ikuo Horii 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 112 KB 👁 1 views

## Abstract The study examined the feasibility of screening for hepatotoxicity by an __in vitro__ gene expression analysis using rat primary hepatocytes and Affymetrix Rat Toxicology U34 arrays. Hepatocytes were exposed for 6 or 24 h to eight drugs, with different mechanisms of hepatotoxicity, at o