Simultaneous analysis of hydrocortisone and hydrocortisone phosphate by high-pressure liquid chromatography: Reversed-phase, ion-pairing approach

✍ Scribed by J. Korpi; D. P. Wittmer; B. J. Sandmann; W. G. Haney Jr.

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 300 KB
• Volume: 65
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600650738

✦ Synopsis

Compounds IVb-IVg were prepared similarly from I11 and the appropriate alcohols (Table I).

p-Chlorophenyl

Benzo[ b]-3-methyl-2-furancarbamate (1Vb)-A solution of I11 (2.01 g, 0.01 mole) and p-chlorophenol(l.28 g, 0.01 mole) in 30 ml of dry benzene was refluxed for 4 hr. The solvent was evaporated, and the residue was crystallized from benzene to give 1.65 g (55%) of the desired compound, mp 155-156'; IR (KBr): 3230