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Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone-type neuroleptics by high performance liquid chromatography with dual ultraviolet detection

✍ Scribed by Yasuhiko Higashi; Miyuki Kitahara; Youichi Fujii


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
123 KB
Volume
20
Category
Article
ISSN
0269-3879

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Simultaneous determination of YM928, a n
✍ Kota Kato; Kiyoshi Noguchi; Toshiko Aoki; Yoshiaki Soeishi; Hidetaka Kamimura πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 285 KB πŸ‘ 2 views

A specific HPLC method for the simultaneous determination of YM928, a novel noncompetitive AMPA receptor antagonist, and its demethylated metabolite (YM-58875) in rat, dog and monkey plasma was developed and validated. The method utilized multiple-step liquid-liquid extraction followed by a reversed