Simultaneous 3D NMR spectroscopy of proton-decoupled fluorine and phosphorus in human liver during 5-fluorouracil chemotherapy

✍ Scribed by Oded Gonen; Joseph Murphy-Boesch; Chun-Wei Li; Kristin Padavic-Shaller; William G. Negendank; Truman R. Brown

• Book ID: 102954988
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 681 KB
• Volume: 37
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910370203

✦ Synopsis

Abstract

Simultaneous acquisition of ^1^H‐decoupled ^31^P and ^19^F 3D CSI is demonstrated in the liver of a patient undergoing 5‐fluorouracil chemotherapy. Both ^31^P and ^19^F shared the same voxel size (64 or 27 ml), bi‐level ^1^H‐decoupling and 0.35 s TR. The measurements were done in a 1.5 Tesla clinical imager with three radio‐frequency (RF) channels and a triple‐tuned surface‐coil. The overall MRI and MRS examination time was under 90 min. Simultaneous acquisition of ^31^P and ^19^F permits localized study of the influence of hepatic metabolism on the uptake and catabolism of fluoropyrimidine drugs without extra measurement time or higher SAR.