Simultaneous 3D NMR spectroscopy of fluorine and phosphorus in human liver during 5-fluorouracil chemotherapy

✍ Scribed by Chun-Wei Li; Oded Gonen

• Book ID: 102953709
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 716 KB
• Volume: 35
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910350609

✦ Synopsis

Abstract

Simultaneous multivoxel ^31^P and ^19^F 3D localized NMR spec‐troscopy is demonstrated on a phantom and in the liver of patients undergoing bolus‐infusion 5‐fluorouracil chemotherapy. The ^19^F and ^31^P spectra were localized with 8 × 8 × 8 3D chemical‐shift imaging, with both nuclei sharing the same field of view and voxel size (27 and 64 ml in phantom and liver, respectively) using a 1.5‐Tesla clinical imager with two RF channels and a dual‐tuned surface coil. The repetition time (TR = 0.26 s) and Ernst nutation angles (θ~E~ = 32° for ^19^F, 28° for ^31^P) were chosen to optimize the signal‐to‐noise ratio (SNR) per‐untt time for the 0.5‐ to 2‐s T~1~ range of the ^19^F and ^31^P metabolites of interest The overall examination time, including tuning, imaging, shimming and dual‐nuclear spectroscopy, was under 90 min. Simultaneous acquisition of ^31^P and ^19^F spectra will permit the study of the influence of hepatic and/or tumor metabolism on the uptake and catabolism of fluoropyrimidine drugs with no extra measurement time.