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Simulated shortening of proliferation-restricting telomeres during clonal proliferation and senescence of human cells

✍ Scribed by Zheng Tan

Book ID: 114253494
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 149 KB
Volume: 36
Category: Article
ISSN: 0531-5565
DOI: 10.1016/s0531-5565(00)00185-6

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## Abstract Human mesenchymal stem cells (MSCs) reside under hypoxic conditions in vivo, between 4% and 7% oxygen. Differentiation of MSCs under hypoxic conditions results in inhibited osteogenesis, while chondrogenesis is unaffected. The reasons for these results may be associated with the inheren