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Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

✍ Scribed by Thomas von Zglinicki; Gabriele Saretzki; Wolf Döcke; Christian Lotze

Book ID
115602153
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
756 KB
Volume
220
Category
Article
ISSN
0014-4827

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Human diploid "broblast cells can divide for only a limited number of times in vitro, a phenomenon known as replicative senescence or the Hay#ick limit. Variability in doubling potential is observed within a clone of cells, and between two sister cells arising from a single mitotic division. This st