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Simple synthesis of 5-vinyl- and5-ethynyl-2′-deoxyuridine-5′-triphosphates

✍ Scribed by Teréz Kovács; Lázló Ötvös

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 225 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)80537-7

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✦ Synopsis

Acid-sensitive nucleoside 5'-0-triphosphates can be obtained in good yield directly from the unprotected nucleosides in the presence of a proton sponge.

In the last decade, numerous pyrimidine nucleoside analogues have proven to be remarkably potent and selective in their activity against herpes simplex virus infections (for recent reviews see ref. 1). These nucleoside analogues all share the common feature that their biological function requires their intracellular conversion to the corresponding 5'-nucleotides.

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