Simple strategy for the synthesis of the avermectin-milbemycin family. Total synthesis of milbemycin .alpha.1
โ Scribed by Hirama, Masahiro; Noda, Takeshi; Yasuda, Shohei; Ito, Sho
- Book ID
- 127107353
- Publisher
- American Chemical Society
- Year
- 1991
- Tongue
- English
- Weight
- 385 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
A highly stereocontrolled synthesis of the Cl 1 to C3 1 fragment of the potent antimicrobial agent milbemycin D has been completed. This approach utilizes a unique hydrolysis-cyclization to construct the spiroketal portion of the molecule. The milbemycins 2 and the avermectins3 are two structurall
The efficient synthesis of C-l to C-10 monocyclic nonaromatic fragments of the milbemycins and avermectins has been achieved, in which the key step involved the stereoselective addition of 2-lithio-4-phenylthiobut-1-ene to a 3-hydroxycyclohexanone derivative.