Simple selected ion monitoring capillary gas chromatographic—mass spectrometric method for the determination of cotinine in serum, urine and oral samples
✍ Scribed by S.A. McAdams; M.L. Cordeiro
- Publisher
- Elsevier Science
- Year
- 1993
- Weight
- 477 KB
- Volume
- 615
- Category
- Article
- ISSN
- 0378-4347
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## Abstract A liquid chromatographic/tandem mass spectrometric method is described for the determination of phencyclidine (PCP) in small volumes of rat serum (e.g. 50 µl). Samples were extracted using a mixed‐mode strong cation‐exchange column and then separated isocratically using a narrow‐bore (2
An analytical procedure for the simultaneous determination of pethidine and norpethidine in plasma by selected ion monitoring is described. The method has a capacity of 15-20 analyses per hour and can be used to determine pethidine and norpethidine down to 25 ng ml-' and 5 ng ml-', respectively. The