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Simple phosphinite–oxazoline ligands for asymmetric catalysis

✍ Scribed by Geraint Jones; Christopher J Richards

Book ID
104231102
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
91 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

4-(Hydroxymethyl)oxazolines, derived from (S)-serine methyl ester and a variety of acid chlorides (RCOCl), were reacted with Ph 2 PCl to give new phosphinite-oxazoline P-N ligands. These mediate the palladium catalysed asymmetric alkylation with dimethyl malonate with the following racemic propenyl substrates R 1 CH CHCH(OX)R 1 : (a) R 1 =Ph, X=Ac-96% e.e.(S) with R=Ph; (b) R 1 =Me, X=CO 2 t Bu-70% e.e.(S) with R=(h 5 -C 5 H 4 )(h 4 -C 4 Ph 4 )Co.

📜 SIMILAR VOLUMES

ChemInform Abstract: Simple Phosphinite—
ChemInform Abstract: Simple Phosphinite—Oxazoline Ligands for Asymmetric Catalysis.
✍ Geraint Jones; Christopher J. Richards 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

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