Simple, high yielding synthesis of trifunctional fluorescent lanthanide chelates
β Scribed by John M.M Griffin; Anna M Skwierawska; H.Charles Manning; John N Marx; Darryl J Bornhop
- Book ID
- 104230686
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 60 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
In an effort to produce strong fluorophores which are conjugated to biologically active substrates, we report a facile, high yielding synthesis of conjugable lanthanide chelates based on the cyclen (1,4,7,10-tetraazacyclododecane) macrocycle.
π SIMILAR VOLUMES
## Abstract A highβyielding synthesis of biologically active spiroβ[cyclopropaneβ1,2β²βsteroids] with a Ξ^4^β²β3β²βone moiety by using the Simmons Smith reaction is described. 2βMethyleneβ4βenβ3βone steroids are treated with methylene iodide (ratio 1:1).
Near quantitative synthesis of 1,4,8-tris(carbamoylmethyl)-l,4,8,11-tetraazacyclotetradecane hydroiodide (1) has been achieved by reacting the parent macrocycle 1,4,8,11-tetraazacyclotetradecane (cyclam) with iodoacetamide in acetone in the presence of diisopropylethylamine as a base. The reaction s