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A simple high-yielding synthesis of spiro[cyclopropane-1,2′-steroids]

✍ Scribed by Desai, Umesh R. ;Trivedi, Girish K.

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
173 KB
Volume
1990
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

A high‐yielding synthesis of biologically active spiro‐[cyclopropane‐1,2′‐steroids] with a Δ^4^′‐3′‐one moiety by using the Simmons Smith reaction is described. 2‐Methylene‐4‐en‐3‐one steroids are treated with methylene iodide (ratio 1:1).

📜 SIMILAR VOLUMES

Conjugation of spirocyclopropane with th
Conjugation of spirocyclopropane with the carbonyl group. Conformational analysis of spiro [cyclopropane-1,2′-steroids]
✍ Umesh R. Desai; Girish K. Trivedi 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 325 KB

o m b a y 4 0 0 076, India The conjugative ability of a spirocyclopropane on 4-en-$one steroids was studied with the help of I3C NMR and two-dimensional experiments such as COSY and NOESY. The conformational analysis of the A ring of these compounds indicates a 'normal' (la,ZB)-half-chair conformati