Simple stereoselective synthesis of (1E,
Simple stereoselective synthesis of (1E,3Z)-4-(substituted)amino 1,3-diethoxycarbonyl-1,3-butadienes
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M. Akram Khan; Harry Adams
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Article
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1999
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Elsevier Science
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French
β 121 KB
Ethyl propynoate reacted with esters of amino acids in methanolic solutions containing sodium acetate to yield the title compounds la-d in 40-52% yields. Some aromatic amines similarly reacted with ethyl propynoate to yield the dienes 3a-h in relatively poor yields (17-45%).