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Simple efficient synthesis of 4-aminoquinazoline via amidine of N-arylamidoxime

✍ Scribed by Sachin S. Patil; Pravin C. Mhaske; Sachin V. Patil; Vivek D. Bobade

Publisher: Journal of Heterocyclic Chemistry
Year: 2011
Tongue: English
Weight: 80 KB
Volume: 48
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.572

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✦ Synopsis

Abstract

Preparation of 4‐amino‐2‐aryl quinazolines by reduction of N‐(2‐cyanoaryl) amidoximes via amidines using SnCl~2~ in ethanol. J. Heterocyclic Chem., (2011).

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## Abstract magnified image A fast, efficient and convenient reaction of 6,7,8‐trimethoxy‐4‐chloroquinazoline and aryl (or benzyl) amines was achieved under microwave irradiation in isopropyl alcohol, providing a simple method for synthesis of novel 6,7,8‐trimethoxy __N__‐substituted‐4‐aminoquinaz