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Microwave assisted synthesis of novel 6,7,8-trimethoxy N-substituted-4-aminoquinazoline compounds

✍ Scribed by Gang Liu; Lin Sun; Chunping Liu; Chunnuan Ji; Quanwu Wen; Songmei Ma

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
281 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A fast, efficient and convenient reaction of 6,7,8‐trimethoxy‐4‐chloroquinazoline and aryl (or benzyl) amines was achieved under microwave irradiation in isopropyl alcohol, providing a simple method for synthesis of novel 6,7,8‐trimethoxy N‐substituted‐4‐aminoquinazoline compounds in good yield in short time. The title compounds were evaluated for their in vitro anti‐proliferative activities against PC3 cell by MTT method.

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