Simple camphor derivatives as chiral auxiliaries for asymmetric conjugate addition
β Scribed by Peter Somfai; David Tanner; Thomas Olsson
- Book ID
- 118549825
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 624 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
## Abstract The conjugate addition of Grignard reagent (**2**) onto 1βΞ±,Ξ²βunsaturated)acyl 3,5βdimethylpyrazole (**1**) was enantioselectively catalyzed by the copper complex from cuprous compounds and 3βphenylβ__l__βmenthoβpyrazole (**3**).
C(l)-substituted (-)-menthone derivatives 3 were prepared by the stereoselective addition of the alkenyllithium reagents 9 to menthone (8) and subsequent acid catalyzed hydrolysis of the dioxolane protecting groups. Conjugate addition of cuprate reagents to enones 3a,b followed by a methanol quench